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What is Game Theory Optimal (GTO) in poker?

The least exploitable fixed strategy, resulting in the highest possible expected value against an opponent that can perfectly exploit you. A strategy is considered to be GTO if it conforms to the principles of Nash Equilibrium; a state where no player can unilaterally change their strategy to increase their expected value. GTO is more loosely used to describe optimal play, although the term is often used in contrast with exploitative strategies.